Iain and Simon review the April 2024 posts, covering bougies, cardiac arrest, trauma and sepsis. They also discuss race in medicine, global health and choosing commitments deliberately, with learning from the RCEM CPD conference and the emergency medicine conference in Graz.
Does combining vitamin C, hydrocortisone and thiamine improve outcomes in septic shock? This 2020 appraisal of ACTS examines its organ dysfunction endpoint, the lack of a demonstrated benefit and how patient selection and treatment in the control group affect interpretation.
Notes from day two of Critical Care Reviews 2020, covering ROSE, CITRIS-ALI and BIRDS, alongside editorial perspectives and the John Hinds Memorial Lecture. These conference highlights signpost research and discussion rather than providing full critical appraisals of every paper.
JC: Critical Care Reviews day 2. #CCR20. St Emlyn's Read More
Did adding vitamin C and thiamine to hydrocortisone improve outcomes in septic shock? This 2020 VITAMINS appraisal examines a randomised comparison that found no improvement in its primary vasopressor-free-time outcome, while discussing the contrast with earlier observational claims and remaining questions about timing and patient selection.
A report from Critical Care Reviews 2020 on the IHME study estimating the global burden of sepsis. It explores geographical and age-related differences, reliance on records and modelling, and why estimates of sepsis-associated deaths do not establish how many deaths were preventable.
JC: The IHME study on the global burden of sepsis. St Emlyn's Read More
A first look at the 65 trial as presented at Critical Care Reviews 2020. The review examines lower blood-pressure targets in older intensive care patients with vasodilatory hypotension, reduced vasopressor exposure and uncertainty around mortality, with a discussion of interpretation beyond statistical significance.
JC: The 65 trial. Targeting MAP in sepsis. St Emlyn's at #CCR20 Read More
The second morning of SMACC 2019 combined innovation with difficult bedside decisions. Topics included productivity, research and CODA’s launch, followed by trauma-related hypotension, severe asthma, uncertainty in sepsis care and a debate about fluids in critical care.
SMACC Day 2 morning sessions: St Emlyn’s Read More
This preview of the September 2018 World Sepsis Conference considers what a free online meeting can offer. Simon Carley reflects on access, diversity, patient voices and the environmental costs of travel, asking how conferences might share learning more widely while retaining the value of meeting in person.
